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Snakes are elongate, legless, carnivorous reptiles of the suborder Serpentes that can be distinguished from legless lizards by their lack of eyelids and external ears. Like all squamates, snakes are ectothermic, amniote vertebrates covered in overlapping scales. Many species of snakes have skulls with many more joints than their lizard ancestors, enabling them to swallow prey much larger than their heads with their highly mobile jaws. To accommodate their narrow bodies, snakes' paired organs (such as kidneys) appear one in front of the other instead of side by side, and most have only one functional lung. Some species retain a pelvic girdle with a pair of vestigial claws on either side of the cloaca.

Living snakes are found on every continent except Antarctica and on most islands. Fifteen families are currently recognized, comprising 456 genera and over 2,900 species. They range in size from the tiny, 10 cm-long thread snake to pythons and anacondas of up to 7.6 meters (25 ft) in length. The fossil species Titanoboa cerrejonensis was 15 meters (49 ft) long. Snakes are thought to have evolved from either burrowing or aquatic lizards during the mid-Cretaceous period, and the earliest known fossils date to around 112 Ma ago. The diversity of modern snakes appeared during the Paleocene period (c 66 to 56 Ma ago).

Most species are nonvenomous and those that have venom use it primarily to kill and subdue prey rather than for self-defense. Some possess venom potent enough to cause painful injury or death to humans. Nonvenomous snakes either swallow prey alive or kill by constriction.

The English word snake comes from Old English snaca, itself from Proto-Germanic *snak-an- (cf. German Schnake "ring snake," Swedish snok "grass snake"), from Proto-Indo-European root *(s)nēg-o- "to crawl, creep," which also gave sneak as well as Sanskrit nāgá "snake." The word ousted adder, as adder went on to narrow in meaning, though in Old English næddre was the general word for snake. The other term, serpent, is from French, ultimately from Indo-European *serp- (to creep), which also gave Greek érpo (ερπω) "I crawl."